Bus Tickets from Knoxville, TN to Myrtle Beach, SC

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Bus Knoxville to Myrtle Beach: Trip Overview

Average Ticket PriceUS$159
Average Bus Trip Duration21h 50m
Number of daily buses1
Earliest bus departure7:20pm
Distance523 km

Knoxville to Myrtle Beach Buses

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Knoxville to Myrtle Beach.

We make sure you can find a bus service from Knoxville to Myrtle Beach from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from Knoxville to Myrtle Beach, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Knoxville - Myrtle Beach

  1. How long is the trip from Knoxville to Myrtle Beach by bus?

    The trip from Knoxville to Myrtle Beach will take on average 21h 50m. For the shortest travel time, select the fastest bus available, which will take you to Myrtle Beach in about 21h 50m.

  2. What is the travel distance from Knoxville to Myrtle Beach?

    The distance between Knoxville and Myrtle Beach is around 525 km (326 miles).

  3. What are the departure and arrival locations for buses traveling from Knoxville to Myrtle Beach?

    Buses traveling this route start their trip at 100 Kirkwood St, in Knoxville, and end it at Bus Station, in Myrtle Beach.

  4. What is the cheapest way to travel from Knoxville to Myrtle Beach?

    The least expensive option to go from Knoxville to Myrtle Beach would be going by bus. With a starting ticket price of US$159, this bus becomes your top pick for this journey.

  5. How much does the bus ticket cost from Knoxville to Myrtle Beach?

    Taking the bus from Knoxville to Myrtle Beach costs on average US$159.

  6. Is there an overnight bus from Knoxville to Myrtle Beach?

    Yes! Catch buses leaving from Knoxville until 7:20pm and reaching Myrtle Beach on the following day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
04-03
US$183
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busbud logoThe cheapest trip from Knoxville to Myrtle Beach was searched and found on Apr 3, 2025 with a price of US$183

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville to Myrtle Beach, as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Knoxville to Myrtle Beach but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Knoxville to Myrtle Beach, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Knoxville to Myrtle Beach that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Knoxville to Myrtle Beach, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Knoxville by bus?

Bus from Knoxville to Myrtle Beach

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