Bus Tickets from Tupelo, MS to Louisville, KY

Find affordable bus tickets from Tupelo, MS to Louisville, KY with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayApr 19
from US$97
TomorrowApr 20
from US$104
MonApr 21
from US$88
TueApr 22
WedApr 23
ThuApr 24
FriApr 25
SatApr 26

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: April 20 at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: April 21 at
    Destination city: Louisville
    Destination location: Louisville, KY
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: April 20 at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: April 21 at
    Destination city: Louisville
    Destination location: Louisville, KY
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Thursday at 7:04 AM CDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Tupelo to Louisville: Trip Overview

Average Ticket PriceUS$104
Average Bus Trip Duration13h 55m
Number of daily buses3
Earliest bus departure5:35am
Distance517 km
Latest bus departure11:15pm

Tupelo to Louisville Bus

Busbud helps you find a bus from Tupelo to Louisville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Tupelo to Louisville.

From cheap bus tickets to more luxurious buses travelling from Tupelo to Louisville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Tupelo - Louisville

  1. How long is the trip from Tupelo to Louisville by bus?

    The bus ride from Tupelo to Louisville takes 13h 55m, on average. If you're looking for the fastest way to get there, you'll find a bus doing the trip in about 11h.

  2. What is the travel distance from Tupelo to Louisville?

    Tupelo and Louisville are 518 km (322 miles) apart.

  3. What is the cheapest way to get from Tupelo to Louisville?

    If you're on a budget, consider traveling by bus to Louisville from Tupelo; it tends to be more affordable. With a starting ticket price of US$87, this bus becomes your top pick for this journey.

  4. How much does the bus ticket cost from Tupelo to Louisville?

    The bus from Tupelo to Louisville will cost you US$104, on average.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
04-17
No data
04-18
No data
Today
US$90
04-20
US$97
04-21
US$80
04-22
No data
04-23
No data
04-24
No data
busbud logoThe cheapest trip from Tupelo to Louisville was searched and found on Apr 21, 2025 with a price of US$80

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Louisville, as early as possible.

You can expect to pay from US$80 to US$151 for a bus ticket from Tupelo to Louisville based on the last 2 days. You can expect to find the cheapest price for the trip at US$80 which is on 2025-04-21.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Tupelo and Louisville!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Tupelo to Louisville.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Tupelo to Louisville that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Tupelo to Louisville.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Tupelo by bus?

Bus from Tupelo to Louisville

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

Popular Buses Connecting Tupelo

Buses Leaving from Tupelo

Buses Going to Tupelo

Popular Buses Connecting Louisville

Buses Leaving from Louisville

Buses Going to Louisville