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- This trip is recommended because it is the: Cheapest + FastestDeparture time: April 27 atDeparture city: Panama CityDeparture location: Panama City Beach StationArrival time: April 28 atDestination city: IndianapolisDestination location: Indianapolis Bus StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration:
Last refresh of the prices: Today at 4:20 AM CDT.
Prices and availability are subject to change.
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Bus Panama City to Indianapolis: Trip Overview
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Based on 86945 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at US$118.00
Panama City to Indianapolis Bus
Busbud helps you find a bus from Panama City to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make sure you can find a bus service from Panama City to Indianapolis from the most reliable bus companies operating this trip.
Whether it is cheap bus tickets or more luxurious buses going to Indianapolis from Panama City, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Panama City and Indianapolis?
Frequently asked questions on the trip Panama City - Indianapolis
How long is the trip from Panama City to Indianapolis by bus?
The trip from Panama City to Indianapolis will take on average 22h 15m. For the shortest travel time, select the fastest bus available, which will take you to Indianapolis in about 22h 15m.
What is the travel distance from Panama City to Indianapolis?
It's about 1071 km (664 miles) from Panama City to Indianapolis.
What are the departure and arrival locations for buses traveling from Panama City to Indianapolis?
Buses departing from Panama City Greyhound Bus Station in Panama City will take you to Greyhound Amtrak Station in Indianapolis.
What is the cheapest way to travel from Panama City to Indianapolis?
The least expensive option to go from Panama City to Indianapolis would be going by bus. The ticket price for this bus starts at US$118, making this your best choice for this trip.
How much does the bus ticket cost from Panama City to Indianapolis?
You can expect to pay around US$170 for the bus ride from Panama City to Indianapolis.
Is there an overnight bus from Panama City to Indianapolis?
Yes! If you're heading from Panama City to Indianapolis, you'll find buses departing until 12:50pm and arriving the next day.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Panama City to Indianapolis was searched and found on May 1, 2025 with a price of US$134To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City to Indianapolis, as early as possible.
You can expect to pay from US$134 to US$182 for a bus ticket from Panama City to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at US$134 which is on 2025-05-01.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Panama City and Indianapolis!
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Panama City to Indianapolis, get comfy and count the stars.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Panama City to Indianapolis.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Panama City to Indianapolis.
Did you know?
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
Top travelled bus routes
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Popular Buses Connecting Panama City
Buses Leaving from Panama City
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Buses Going to Panama City
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Popular Buses Connecting Indianapolis
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Buses Going to Indianapolis
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Popular routes in this country
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