Find coaches from Buffalo, NY to Greenville, SC

Today31 Jul
Tomorrow1 Aug
Sat2 Aug
Sun3 Aug
Mon4 Aug
Tue5 Aug
Wed6 Aug
from US$99
Thu7 Aug

Cheap buses leaving Wednesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 6 August at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: 7 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 6 August at
    Departure city: Buffalo
    Departure location: Buffalo (BUF) Airport
    Arrival time: 7 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 6 August at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: 7 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 6 August at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: 8 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 6 August at
    Departure city: Buffalo
    Departure location: Buffalo (BUF) Airport
    Arrival time: 7 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to travel from Buffalo to Greenville

Bus
Average priceUS$101 - US$236Average duration1d 1h
24kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average priceUS$225 - US$275Average duration1d
86kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the bus from Buffalo to Greenville

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 1 day, 1 hour 5 minutes and with fares starting at just US$101, it presents an excellent value for a comfortable ride.

7bus per day
1d 1hAverage duration
US$101Cheapest ticket
24kgCO₂ emissions

Bus Buffalo, NY to Greenville, SC: Trip Overview

Average ticket priceUS$157
Average bus trip duration1d 1h
Number of daily buses7
Earliest bus departure07:30
Distance585 miles
Latest bus departure23:59

Buffalo to Greenville Bus

Busbud helps you find a bus from Buffalo to Greenville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Buffalo to Greenville will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Buffalo to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Buffalo, NY - Greenville, SC

  1. How far is Greenville from Buffalo by coach?

    The journey from Buffalo to Greenville by coach covers an approximate distance of 586 miles (945 km).

  2. What is the best way to go from Buffalo to Greenville without flying?

    You can choose the coach to travel this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
29/07
No data
30/07
US$216
Today
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01/08
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busbud logoThe cheapest trip from Buffalo, NY to Greenville, SC was searched and found on 30 Jul 2025 with a price of US$216

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Buffalo, NY to Greenville, SC as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Buffalo and Greenville!

Much more than a mere vehicle taking you from Buffalo to Greenville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Buffalo to Greenville that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Buffalo to Greenville.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

What's the cheapest way to go from Buffalo, NY to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Buffalo, NY by bus?

Bus from Buffalo, NY to Greenville, SC

You can also go to Greenville, SC by train

Train from Buffalo, NY to Greenville, SC

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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