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- This trip is recommended because it is: CheapestDeparture time: May 1 atDeparture city: PragueDeparture location: Prague (Central Bus Station Florenc)Arrival time: May 2 atDestination city: BrusselsDestination location: Brussels South (Gare du Midi)Operated by: Flixbus
Vehicle: BusDuration: - This trip is recommended because it is: FastestDeparture time: May 1 atDeparture city: PragueDeparture location: Prague (Na Knížecí)Arrival time: May 1 atDestination city: BrusselsDestination location: Brussels-North (Gare du Nord)Operated by: FlixbusVehicle: BusDuration:
- Departure time: May 1 atDeparture city: PragueDeparture location: Prague (Central Bus Station Florenc)Arrival time: May 2 atDestination city: BrusselsDestination location: Brussels AirportOperated by: FlixbusVehicle: BusDuration:
- Departure time: May 1 atDeparture city: PragueDeparture location: Prague (Central Bus Station Florenc)Arrival time: May 2 atDestination city: BrusselsDestination location: Brussels AirportOperated by: FlixbusVehicle: BusDuration:
- Departure time: May 1 atDeparture city: PragueDeparture location: Prague (Central Bus Station Florenc)Arrival time: May 2 atDestination city: BrusselsDestination location: Brussels AirportOperated by: FlixbusVehicle: BusDuration:
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Compare 2 ways to go from Prague to Brussels.
Busbud recommends taking the bus from Prague to BrusselsAmong the sustainable travel choices, the bus stands out as the good way to reach Brussels. The journey takes about 18 hours 30 minutes and with fares starting at just $42, it presents an excellent value for a comfortable ride.
Bus Prague to Brussels: Trip Overview
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Prague to Brussels Bus
With Busbud, comparing and booking tickets for a bus from Prague to Brussels is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make sure you can find a bus service from Prague to Brussels from the most reliable bus companies operating this trip.
Whether it is cheap bus tickets or more luxurious buses going to Brussels from Prague, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Prague and Brussels?
Frequently asked questions for your trip Prague - Brussels
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Brussels was searched and found on May 5, 2025 with a price of $50To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Brussels, as early as possible.
You can expect to pay from $50 to $171 for a bus ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $50 which is on 2025-05-05.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while traveling from Prague to Brussels.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Prague to Brussels, get comfy and count the stars.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Prague to Brussels.
Make a music playlist for your bus ride from Prague to Brussels, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
What's the cheapest way to go from Prague to Brussels?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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