Bus Tickets from Chicago, IL to Des Moines, IA

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SunApr 27
from $59
MonApr 28
from $47
TueApr 29
from $40
WedApr 30
from $40
ThuMay 1
from $40
FriMay 2
from $45
SatMay 3
SunMay 4

Cheap buses leaving Monday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: April 28 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: April 28 at
    Destination city: Des Moines
    Destination location: Des Moines (Subway)
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: April 28 at
    Departure city: Chicago
    Departure location: Chicago
    Arrival time: April 28 at
    Destination city: Des Moines
    Destination location: Des Moines
    Operated by: Burlington TrailwaysBurlington Trailways
    Vehicle: BusDuration:
  • Departure time: April 28 at
    Departure city: Chicago
    Departure location: Chicago
    Arrival time: April 28 at
    Destination city: Des Moines
    Destination location: Des Moines
    Operated by: Burlington TrailwaysBurlington Trailways
    Vehicle: BusDuration:
  • Departure time: April 28 at
    Departure city: Chicago
    Departure location: Chicago
    Arrival time: April 28 at
    Destination city: Des Moines
    Destination location: Des Moines
    Operated by: Burlington TrailwaysBurlington Trailways
    Vehicle: BusDuration:
  • Departure time: April 28 at
    Departure city: Chicago
    Departure location: Chicago
    Arrival time: April 28 at
    Destination city: Des Moines
    Destination location: Des Moines
    Operated by: Burlington TrailwaysBurlington Trailways
    Vehicle: BusDuration:

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Bus Chicago to Des Moines: Trip Overview

Average ticket price$58
Average bus trip duration11h 40m
Number of daily buses3
Earliest bus departure6:10am
Distance307 miles (494 km)
Latest bus departure11:50pm

Chicago to Des Moines Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Chicago to Des Moines.

Bus service from Chicago to Des Moines will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Des Moines from Chicago, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Chicago - Des Moines

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
04/23
$63
04/24
$59
Today
$63
04/26
$61
04/27
$59
04/28
$47
04/29
$40
04/30
$40
busbud logoThe cheapest trip from Chicago to Des Moines was searched and found on Apr 29, 2025 with a price of $40

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Des Moines, as early as possible.

You can expect to pay from $40 to $155 for a bus ticket from Chicago to Des Moines based on the last 2 days. You can expect to find the cheapest price for the trip at $40 which is on 2025-04-29.

Usually Burlington Trailways will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Chicago to Des Moines but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Chicago to Des Moines, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Chicago to Des Moines.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Chicago to Des Moines.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to Chicago by bus?

Bus from Chicago to Des Moines

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