Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Cincinnati Bus Station | Knoxville Bus Station | CheapestFastest |
Last refresh of the prices: Last Thursday at 8:52 PM EST.
Get from Cincinnati to Knoxville
The journey takes about 5 hours 35 minutes and with fares starting at just $43, it presents an excellent value for a comfortable ride.
Where are the popular stops in Cincinnati and Knoxville?
Stops in Cincinnati
- A1005 Gilbert Ave, Cincinnati, OH 45202
- B
Northland Blvd
290-322 Northland Blvd, Springdale, OH 45246, USA
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Cincinnati Knoxville recent customer reviews
30 minute delay plus air conditioner was broken on bus very uncomfortable for my very first bus ride
Jaicelyn T.
Driver was a substitute for absent driver and very apprehensive about anyone approaching or talking with a moderate decibel. Bus felt like the The front was shaking due to an unbalanced tire. When inquiring with the bus driver he said he had to leave the resistant break on from the time we left Lexington until Knoxville
Michael N.
Frequently asked questions about traveling from Cincinnati to Knoxville, TN by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Cincinnati to Knoxville?
The cheapest bus tickets from Cincinnati to Knoxville start from $43. The average price for this route is around $58. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Cincinnati to Knoxville?
The average bus trip duration from Cincinnati to Knoxville is 5h 35m, covering a distance of 224 miles (362 km). The quickest bus can get you there in 5h 35m and is operated by Greyhound.
Which bus companies service the Cincinnati to Knoxville route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the bus from Cincinnati to Knoxville?
The earliest bus departs from Cincinnati to Knoxville at 1:20pm. And the latest bus departs at 1:20pm.
What are the CO₂ emissions for the bus trip from Cincinnati to Knoxville?
A bus trip from Cincinnati to Knoxville generates an estimated 9 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Cincinnati to Knoxville, TN was searched and found on Dec 13, 2025 with a price of $46To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Cincinnati to Knoxville, TN, as early as possible.
You can expect to pay from $46 to $46 for a bus ticket from Cincinnati to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $46 which is on 2025-12-19.
Top traveled bus routes
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