Bus Panama City to Chicago: Trip Overview
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Panama City to Chicago Bus
Busbud helps you find a bus from Panama City to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make it our job to connect you with the most dependable bus companies that cover bus service from Panama City to Chicago.
Discover how much the bus trip from Panama City to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Panama City and Chicago?
Frequently asked questions for your trip Panama City - Chicago
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Panama City to Chicago was searched and found on Apr 24, 2025 with a price of $201To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City to Chicago, as early as possible.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Panama City and Chicago!
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Panama City to Chicago.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Panama City to Chicago will emit less CO2 than a car or an airplane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Panama City to Chicago.
Did you know?
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.
Top traveled bus routes
Why choose Busbud?
The Best Way To Book Bus and Train Tickets
Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
Popular Buses Connecting Panama City
Buses Leaving from Panama City
- Bus from Panama City to Long Beach
- Bus Panama City - Miami
- Panama City - San Jose
- Bus from Panama City to Orlando
- Bus Panama City - Tallahassee
- Panama City - Gainesville
- Bus from Panama City to Atlanta
- Bus Panama City - Tampa
- Panama City - Fort Lauderdale
- Bus from Panama City to Jacksonville
- Bus Panama City - New York
- Panama City - Biloxi
- Bus from Panama City to Gainesville
- Bus Panama City - New Orleans
- Panama City - Birmingham
Buses Going to Panama City
- Bus from Miami to Panama City
- Bus Atlanta - Panama City
- Tallahassee - Panama City
- Bus from Tampa to Panama City
- Bus Chicago - Panama City
- Long Beach - Panama City
- Bus from San Jose to Panama City
- Bus Orlando - Panama City
- Jacksonville - Panama City
- Bus from Fort Lauderdale to Panama City
- Bus New Orleans - Panama City
- Houston - Panama City
- Bus from New York to Panama City
- Bus Nashville - Panama City
- Lake City - Panama City