Bus Tupelo to Chicago: Trip Overview
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Tupelo to Chicago Buses
With Busbud, comparing and booking tickets for a bus from Tupelo to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make sure you can find a bus service from Tupelo to Chicago from the most reliable bus companies operating this trip.
Discover how much the bus trip from Tupelo to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Frequently asked questions for your trip Tupelo - Chicago
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to Chicago was searched and found on Apr 14, 2025 with a price of $96To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Chicago, as early as possible.
You can expect to pay from $96 to $219 for a bus ticket from Tupelo to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $96 which is on 2025-04-14.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while traveling from Tupelo to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Tupelo to Chicago, get comfy and count the stars.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Tupelo to Chicago will emit less CO2 than a car or an airplane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Tupelo to Chicago.
Did you know?
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
Top traveled bus routes
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Popular Buses Connecting Tupelo
Buses Leaving from Tupelo
- Bus from Tupelo to Gainesville
- Bus Tupelo - Gainesville
- Tupelo - Jackson
- Bus from Tupelo to Jackson
- Bus Tupelo - Milwaukee
- Tupelo - Memphis
- Bus from Tupelo to Atlanta
- Bus Tupelo - Dallas
- Tupelo - Chicago
- Bus from Tupelo to Nashville
- Bus Tupelo - Grand Rapids
- Tupelo - Houston
- Bus from Tupelo to Orlando
- Bus Tupelo - Birmingham
- Tupelo - New York
Buses Going to Tupelo
- Bus from Nashville to Tupelo
- Bus Harrisburg - Tupelo
- Memphis - Tupelo
- Bus from Atlanta to Tupelo
- Bus Biloxi - Tupelo
- Dallas - Tupelo
- Bus from Houston to Tupelo
- Bus St Louis - Tupelo
- Birmingham - Tupelo
- Bus from Jackson to Tupelo
- Bus Tampa - Tupelo
- Chicago - Tupelo
- Bus from Orlando to Tupelo
- Bus Meridian - Tupelo
- New York - Tupelo