Find coaches from Greenville, SC to Chicago, IL

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Today2 Apr
Tomorrow3 Apr
Fri4 Apr
from US$117
Sat5 Apr
Sun6 Apr
Mon7 Apr
Tue8 Apr
Wed9 Apr

Cheap buses leaving Friday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 4 April at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: 5 April at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 4 April at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: 5 April at
    Destination city: Chicago
    Destination location: 537-517 W. Jackson Blvd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 4 April at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: 6 April at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 4 April at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: 5 April at
    Destination city: Chicago
    Destination location: 537-517 W. Jackson Blvd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Greenville to Chicago: Trip Overview

Average ticket priceUS$126
Average bus trip duration21h 55m
Number of daily buses10
Earliest bus departure12:55
Distance556 miles
Latest bus departure22:15

Greenville to Chicago buses

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Greenville to Chicago.

We make it our job to connect you with the most dependable bus companies that cover bus service from Greenville to Chicago.

Whether it is cheap bus tickets or more luxurious buses going to Chicago from Greenville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Greenville - Chicago

  1. How much does the Greenville Chicago coach trip cost?

    For coach travel from Greenville to Chicago, ticket prices typically start at US$90 and can reach a maximum of US$388. The cost of tickets can fluctuate based on factors like the time of day, the company, and the class you choose. Use Busbud to compare prices and amenities offered by different companies, ensuring you find the most favorable deals and promotions.

  2. How long is the coach ride from Greenville to Chicago?

    The average duration for a trip from Greenville to Chicago by coach is around 21h 55m. If you're looking for the fastest trip, you can get there in just about 20h. Please be aware that the time it takes for your journey may vary depending on the traffic conditions along the route.

  3. At what time is the first coach from Greenville to Chicago?

    The first departure to Chicago is at 12:55. Times and services may vary during weekends and holidays.

  4. How far is Chicago from Greenville by coach?

    The distance between Greenville and Chicago by coach is approximately 561 miles (904 km).

  5. What is the best way to go from Greenville to Chicago without flying?

    You have the option to select the coach for your journey on this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
31/03
US$110
01/04
US$122
Today
No data
03/04
No data
04/04
US$117
05/04
US$121
06/04
US$115
07/04
US$99
busbud logoThe cheapest trip from Greenville to Chicago was searched and found on 7 Apr 2025 with a price of US$99

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville to Chicago as early as possible.

You can expect to pay from US$99 to US$156 for a bus ticket from Greenville to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$99, which is on 2025-04-07.

Usually Greyhound Lines, Inc. will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Greenville to Chicago but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Greenville to Chicago.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Greenville to Chicago.

Make a music playlist for your bus ride from Greenville to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Greenville to Chicago?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Greenville by bus?

Bus from Greenville to Chicago

You can also go to Chicago by train

Train from Greenville to Chicago

Why choose Busbud?

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Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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