Bus Tickets from Boston, MA to Greenville, SC

Find affordable bus tickets from Boston, MA to Greenville, SC with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
FriApr 25
SatApr 26
SunApr 27
from $136
MonApr 28
TueApr 29
WedApr 30
ThuMay 1
FriMay 2

Cheap buses leaving Sunday

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: April 27 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: April 28 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: April 27 at
    Departure city: Boston
    Departure location: Boston
    Arrival time: April 28 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: April 27 at
    Departure city: Boston
    Departure location: 151 Steel Pl, Cambridge
    Arrival time: April 28 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Boston to Greenville: Trip Overview

Average ticket price$128
Average bus trip duration22h 5m
Number of daily buses8
Earliest bus departure1:30am
Distance797 miles (1285 km)
Latest bus departure8:55pm

Boston to Greenville Bus

Busbud helps you find a bus from Boston to Greenville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Boston to Greenville will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from Boston, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Boston - Greenville

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
04/21
$103
04/22
$204
Today
No data
04/24
$95
04/25
No data
04/26
$86
04/27
$136
04/28
$154
busbud logoThe cheapest trip from Boston to Greenville was searched and found on Apr 26, 2025 with a price of $86

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston to Greenville, as early as possible.

You can expect to pay from $86 to $216 for a bus ticket from Boston to Greenville based on the last 2 days. You can expect to find the cheapest price for the trip at $86 which is on 2025-04-26.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Boston and Greenville!

Much more than a mere vehicle taking you from Boston to Greenville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Boston to Greenville.

Tune out to the fine sounds of your best music playlist on your bus trip from Boston to Greenville while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Boston to Greenville?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Boston by bus?

Bus from Boston to Greenville

You can also go to Greenville by train

Train from Boston to Greenville

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

Popular Buses Connecting Boston

Buses Leaving from Boston

Buses Going to Boston

Popular Buses Connecting Greenville

Buses Leaving from Greenville

Buses Going to Greenville