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- This trip is recommended because it is: Cheapest + FastestDeparture time: April 26 atDeparture city: CharlestonDeparture location: Charleston Bus StationArrival time: April 26 atDestination city: KnoxvilleDestination location: Knoxville Bus StationOperated by: Greyhound Lines, Inc.
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Bus Charleston to Knoxville: Trip Overview
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Charleston to Knoxville Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Charleston to Knoxville.
We make it our job to connect you with the most dependable bus companies that cover bus service from Charleston to Knoxville.
From cheap bus tickets to more luxurious buses traveling from Charleston to Knoxville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Charleston and Knoxville?
Frequently asked questions for your trip Charleston - Knoxville
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Charleston to Knoxville was searched and found on Apr 28, 2025 with a price of $67To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Charleston to Knoxville, as early as possible.
You can expect to pay from $67 to $86 for a bus ticket from Charleston to Knoxville based on the last 2 days. You can expect to find the cheapest price for the trip at $67 which is on 2025-04-28.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Charleston to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Charleston to Knoxville.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Charleston to Knoxville that are otherwise impossible to come by with a plane.
Make a music playlist for your bus ride from Charleston to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
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Popular Buses Connecting Charleston
Buses Leaving from Charleston
- Bus from Charleston to Lawrence
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Buses Going to Charleston
- Bus from Myrtle Beach to Charleston
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- Lexington - Charleston
- Bus from Chicago to Charleston
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Popular Buses Connecting Knoxville
Buses Leaving from Knoxville
- Bus from Knoxville to Charlotte
- Bus Knoxville - Orlando
- Knoxville - Lexington
- Bus from Knoxville to Chicago
- Bus Knoxville - New York
- Knoxville - Miami
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- Bus Knoxville - Atlanta
- Knoxville - Memphis
- Bus from Knoxville to Washington
- Bus Knoxville - Jackson
- Knoxville - Dallas
- Bus from Knoxville to Cincinnati
- Bus Knoxville - Philadelphia
Buses Going to Knoxville
- Bus from Nashville to Knoxville
- Bus Memphis - Knoxville
- Charlotte - Knoxville
- Bus from Chicago to Knoxville
- Bus Tampa - Knoxville
- Richmond - Knoxville
- Bus from Atlanta to Knoxville
- Bus New York - Knoxville
- Dallas - Knoxville
- Bus from Greenville to Knoxville
- Bus Louisville - Knoxville
- Cookeville - Knoxville
- Bus from Washington to Knoxville
- Bus Lexington - Knoxville
- Baltimore - Knoxville