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- This trip is recommended because it is: CheapestDeparture time: April 28 atDeparture city: ChicagoDeparture location: Downtown Greyhound StationArrival time: April 29 atDestination city: GreenvilleDestination location: 1116 Woodruff RdOperated by: FlixBus
Vehicle: BusDuration: - This trip is recommended because it is: FastestDeparture time: April 28 atDeparture city: ChicagoDeparture location: 537-517 W. Jackson BlvdArrival time: April 29 atDestination city: GreenvilleDestination location: 1116 Woodruff RdOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration: - Departure time: April 28 atDeparture city: ChicagoDeparture location: Downtown Greyhound StationArrival time: April 29 atDestination city: GreenvilleDestination location: 1116 Woodruff RdOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
- Departure time: April 28 atDeparture city: ChicagoDeparture location: Chicago 95Th & Dan RyanArrival time: April 29 atDestination city: GreenvilleDestination location: 1116 Woodruff RdOperated by: FlixBusVehicle: BusDuration:
- Departure time: April 28 atDeparture city: ChicagoDeparture location: Downtown Greyhound StationArrival time: April 30 atDestination city: GreenvilleDestination location: 1116 Woodruff RdOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
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Compare 2 ways to go from Chicago to Greenville.
Busbud recommends taking the bus from Chicago to GreenvilleAmong the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 20 hours 55 minutes and with fares starting at just $82, it presents an excellent value for a comfortable ride.
Bus Chicago to Greenville: Trip Overview
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Chicago to Greenville Bus
Busbud helps you find a bus from Chicago to Greenville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make sure you can find a bus service from Chicago to Greenville from the most reliable bus companies operating this trip.
From cheap bus tickets to more luxurious buses traveling from Chicago to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Chicago and Greenville?
Frequently asked questions for your trip Chicago - Greenville
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Greenville was searched and found on May 1, 2025 with a price of $86To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Greenville, as early as possible.
You can expect to pay from $86 to $162 for a bus ticket from Chicago to Greenville based on the last 2 days. You can expect to find the cheapest price for the trip at $86 which is on 2025-05-01.
Usually Greyhound Lines, Inc. will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Chicago and Greenville!
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Chicago to Greenville, get comfy and count the stars.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Chicago to Greenville that are otherwise impossible to come by with a plane.
Make a music playlist for your bus ride from Chicago to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
What's the cheapest way to go from Chicago to Greenville?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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