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One passenger / one way
- This trip is recommended because it is: Cheapest + FastestDeparture time: April 26 atDeparture city: Myrtle BeachDeparture location: Bus StationArrival time: April 27 atDestination city: KnoxvilleDestination location: Knoxville Bus StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration:
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Bus Myrtle Beach to Knoxville: Trip Overview
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Myrtle Beach to Knoxville Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Myrtle Beach to Knoxville.
We make sure you can find a bus service from Myrtle Beach to Knoxville from the most reliable bus companies operating this trip.
Discover how much the bus trip from Myrtle Beach to Knoxville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Myrtle Beach and Knoxville?
Frequently asked questions for your trip Myrtle Beach - Knoxville
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Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Myrtle Beach to Knoxville was searched and found on Apr 26, 2025 with a price of $136To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Myrtle Beach to Knoxville, as early as possible.
You can expect to pay from $136 to $136 for a bus ticket from Myrtle Beach to Knoxville based on the last 2 days. You can expect to find the cheapest price for the trip at $136 which is on 2025-04-26.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Myrtle Beach to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Myrtle Beach to Knoxville, get comfy and count the stars.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Myrtle Beach to Knoxville will emit less CO2 than a car or an airplane.
Make a music playlist for your bus ride from Myrtle Beach to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
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Popular Buses Connecting Myrtle Beach
Buses Leaving from Myrtle Beach
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Buses Going to Myrtle Beach
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- Bus from Chicago to Myrtle Beach
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- Bus from New York to Myrtle Beach
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- Atlanta - Myrtle Beach
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Popular Buses Connecting Knoxville
Buses Leaving from Knoxville
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- Knoxville - Dallas
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Buses Going to Knoxville
- Bus from Nashville to Knoxville
- Bus Memphis - Knoxville
- Charlotte - Knoxville
- Bus from Chicago to Knoxville
- Bus Tampa - Knoxville
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- Bus from Atlanta to Knoxville
- Bus New York - Knoxville
- Dallas - Knoxville
- Bus from Greenville to Knoxville
- Bus Louisville - Knoxville
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- Bus from Washington to Knoxville
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- Baltimore - Knoxville