Bus Tickets from San Francisco, CA to Buffalo, NY

Find affordable bus tickets from San Francisco, CA to Buffalo, NY with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TomorrowApr 26
SunApr 27
from $261
MonApr 28
TueApr 29
WedApr 30
ThuMay 1
FriMay 2
SatMay 3

Next departures to Buffalo

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: April 27 at
    Departure city: San Francisco
    Departure location: San Francisco Bus Station
    Arrival time: April 30 at
    Destination city: Buffalo
    Destination location: Niagara Frontier Transportation Authority
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: April 27 at
    Departure city: San Francisco
    Departure location: Mission St & Fremont St
    Arrival time: April 30 at
    Destination city: Buffalo
    Destination location: Depew Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: April 27 at
    Departure city: San Francisco
    Departure location: Mission St & Fremont St
    Arrival time: April 30 at
    Destination city: Buffalo
    Destination location: Depew Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: April 27 at
    Departure city: San Francisco
    Departure location: Mission St & Fremont St
    Arrival time: April 30 at
    Destination city: Buffalo
    Destination location: Depew Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus San Francisco to Buffalo: Trip Overview

Average ticket price$209
Average bus trip duration3d 17h
Number of daily buses6
Earliest bus departure6:00am
Distance2295 miles (3701 km)
Latest bus departure11:25pm

San Francisco to Buffalo Bus

With Busbud, comparing and booking tickets for a bus from San Francisco to Buffalo is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from San Francisco to Buffalo from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Buffalo from San Francisco, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip San Francisco - Buffalo

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
04/23
No data
04/24
No data
Today
No data
04/26
No data
04/27
$261
04/28
No data
04/29
No data
04/30
No data
busbud logoThe cheapest trip from San Francisco to Buffalo was searched and found on Apr 27, 2025 with a price of $261

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Francisco to Buffalo, as early as possible.

You can expect to pay from $261 to $1,334 for a bus ticket from San Francisco to Buffalo based on the last 2 days. You can expect to find the cheapest price for the trip at $261 which is on 2025-04-27.

Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from San Francisco to Buffalo.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Francisco to Buffalo, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from San Francisco to Buffalo.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Francisco to Buffalo.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to San Francisco by bus?

Bus from San Francisco to Buffalo

You can also go to Buffalo by train

Train from San Francisco to Buffalo

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

People from around the world trust Busbud

‌

Popular Buses Connecting San Francisco

Buses Leaving from San Francisco

Buses Going to San Francisco

Popular Buses Connecting Buffalo

Buses Leaving from Buffalo

Buses Going to Buffalo