Bus Tickets from San Luis Obispo, CA to Santa Clara, CA

Find affordable bus tickets from San Luis Obispo, CA to Santa Clara, CA with flexible options. Book your trip now

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WedApr 30
from $53
ThuMay 1
from $53
FriMay 2
SatMay 3
SunMay 4
from $64
MonMay 5
TueMay 6
WedMay 7

Next departures to Santa Clara

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: May 1 at
    Departure city: San Luis Obispo
    Departure location: Cal Poly Vista Grande Dining Complex
    Arrival time: May 1 at
    Destination city: Santa Clara
    Destination location: Santa Ana Regional Transportation Center
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: May 1 at
    Departure city: San Luis Obispo
    Departure location: Cal Poly Vista Grande Dining Complex
    Arrival time: May 1 at
    Destination city: Santa Clara
    Destination location: Santa Clara Transit Center
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: May 1 at
    Departure city: San Luis Obispo
    Departure location: Cal Poly Vista Grande Dining Complex
    Arrival time: May 1 at
    Destination city: Santa Clara
    Destination location: Great America Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: May 1 at
    Departure city: San Luis Obispo
    Departure location: Cal Poly Vista Grande Dining Complex
    Arrival time: May 1 at
    Destination city: Santa Clara
    Destination location: Great America Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: May 1 at
    Departure city: San Luis Obispo
    Departure location: Cal Poly Vista Grande Dining Complex
    Arrival time: May 1 at
    Destination city: Santa Clara
    Destination location: Great America Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:

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Compare 2 ways to go from San Luis Obispo to Santa Clara.

Bus
Average Price$76 - $78Average Duration8h 15m
8kg CO₂e5 out of 5 stars
Most eco-friendly
Train
Average Price$49 - $70Average Duration6h 48m
28kg CO₂e1 out of 5 stars
CheapestFastest
busbud logoBusbud recommends taking the train from San Luis Obispo to Santa Clara

Among the sustainable travel choices, the train stands out as the good way to reach Santa Clara. The journey takes about 6 hours 48 minutes and with fares starting at just $49, it presents an excellent value for a comfortable ride.

2train per day
6h 48mAverage Duration
$49Cheapest ticket
28kgCO₂ emissions

Bus San Luis Obispo to Santa Clara: Trip Overview

Average ticket price$76
Average bus trip duration8h 15m
Number of daily buses2
Earliest bus departure6:50pm
Distance191 miles (307 km)
Latest bus departure7:25pm

San Luis Obispo to Santa Clara Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from San Luis Obispo to Santa Clara.

We make it our job to connect you with the most dependable bus companies that cover bus service from San Luis Obispo to Santa Clara.

Discover how much the bus trip from San Luis Obispo to Santa Clara will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip San Luis Obispo - Santa Clara

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
04/26
$53
04/27
$53
Today
$53
04/29
$53
04/30
$53
05/01
$53
05/02
$53
05/03
$53
busbud logoThe cheapest trip from San Luis Obispo to Santa Clara was searched and found on Apr 26, 2025 with a price of $53

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to Santa Clara, as early as possible.

You can expect to pay from $53 to $108 for a bus ticket from San Luis Obispo to Santa Clara based on the last 2 days. You can expect to find the cheapest price for the trip at $53 which is on 2025-04-29.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from San Luis Obispo to Santa Clara but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from San Luis Obispo to Santa Clara.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from San Luis Obispo to Santa Clara will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from San Luis Obispo to Santa Clara while indulging in miles on end of beautiful scenic views.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to San Luis Obispo by bus?

Bus from San Luis Obispo to Santa Clara

You can also go to Santa Clara by train

Train from San Luis Obispo to Santa Clara

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Popular Buses Connecting San Luis Obispo

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Popular Buses Connecting Santa Clara

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