Bus Tickets from Santa Cruz to Santiago

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TodayApr 28
from $7
TomorrowApr 29
from $7
WedApr 30
from $7
ThuMay 1
FriMay 2
SatMay 3
from $7
SunMay 4
MonMay 5

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: April 29 at
    Departure city: Santa Cruz
    Departure location: Terminal Santa Cruz
    Arrival time: April 29 at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: AndimarAndimar
    Vehicle: BusDuration:
  • Departure time: April 29 at
    Departure city: Santa Cruz
    Departure location: Terminal Santa Cruz
    Arrival time: April 29 at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: Buses Jet SurBuses Jet Sur
    Vehicle: BusDuration:
  • Departure time: April 29 at
    Departure city: Santa Cruz
    Departure location: Terminal Santa Cruz
    Arrival time: April 29 at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: Buses TranSantinBuses TranSantin
    Vehicle: BusDuration:
  • Departure time: April 29 at
    Departure city: Santa Cruz
    Departure location: Terminal Santa Cruz
    Arrival time: April 29 at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: AndimarAndimar
    Vehicle: BusDuration:
  • Departure time: April 29 at
    Departure city: Santa Cruz
    Departure location: Terminal Santa Cruz
    Arrival time: April 29 at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: Buses Jet SurBuses Jet Sur
    Vehicle: BusDuration:

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Bus Santa Cruz to Santiago: Trip Overview

Average ticket price$8
Average bus trip duration3h
Number of daily buses22
Earliest bus departure5:00am
Distance91 miles (146 km)
Latest bus departure9:35pm

Santa Cruz to Santiago Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Santa Cruz to Santiago.

We make sure you can find a bus service from Santa Cruz to Santiago from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Santiago from Santa Cruz, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Santa Cruz - Santiago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
04/26
$7
04/27
$8
Today
$7
04/29
$7
04/30
$7
05/01
$7
05/02
$7
05/03
$7
busbud logoThe cheapest trip from Santa Cruz to Santiago was searched and found on May 1, 2025 with a price of $7

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Cruz to Santiago, as early as possible.

You can expect to pay from $7 to $10 for a bus ticket from Santa Cruz to Santiago based on the last 2 days. You can expect to find the cheapest price for the trip at $7 which is on 2025-05-01.

Usually Buses Jet Sur will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Santa Cruz to Santiago but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santa Cruz to Santiago, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Santa Cruz to Santiago.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santa Cruz to Santiago.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Will you be returning to Santa Cruz by bus?

Bus from Santa Cruz to Santiago

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