Next departures to Chicago
One passenger / one way
- This trip is recommended because it is: CheapestDeparture time: April 26 atDeparture city: St LouisDeparture location: Gateway StationArrival time: April 26 atDestination city: ChicagoDestination location: Downtown Greyhound StationOperated by: FlixBus
Vehicle: BusDuration: - This trip is recommended because it is: FastestDeparture time: April 26 atDeparture city: St LouisDeparture location: Gateway StationArrival time: April 26 atDestination city: ChicagoDestination location: Chicago 95Th & Dan RyanOperated by: FlixBusVehicle: BusDuration:
- Departure time: April 26 atDeparture city: St LouisDeparture location: Gateway StationArrival time: April 27 atDestination city: ChicagoDestination location: Chicago (Union Station), ILOperated by: Amtrak
Vehicle: BusDuration: - Departure time: April 26 atDeparture city: St LouisDeparture location: Gateway StationArrival time: April 26 atDestination city: ChicagoDestination location: Downtown Greyhound StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration: - Departure time: April 26 atDeparture city: St LouisDeparture location: Gateway StationArrival time: April 26 atDestination city: ChicagoDestination location: Chicago 95Th & Dan RyanOperated by: FlixBusVehicle: BusDuration:
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Bus St Louis to Chicago: Trip Overview
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St Louis to Chicago Bus
Busbud helps you find a bus from St Louis to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make it our job to connect you with the most dependable bus companies that cover bus service from St Louis to Chicago.
Whether it is cheap bus tickets or more luxurious buses going to Chicago from St Louis, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in St Louis and Chicago?
Frequently asked questions for your trip St Louis - Chicago
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St Louis to Chicago was searched and found on Apr 22, 2025 with a price of $25To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St Louis to Chicago, as early as possible.
You can expect to pay from $25 to $228 for a bus ticket from St Louis to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $25 which is on 2025-04-26.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between St Louis and Chicago!
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from St Louis to Chicago.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St Louis to Chicago.
Make a music playlist for your bus ride from St Louis to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
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