Bus Tickets from St Louis, MO to Greenville, SC

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TodayApr 25
TomorrowApr 26
SunApr 27
from $113
MonApr 28
TueApr 29
WedApr 30
ThuMay 1
FriMay 2

Cheap buses leaving Sunday

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: April 27 at
    Departure city: St Louis
    Departure location: Gateway Station
    Arrival time: April 28 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus St Louis to Greenville: Trip Overview

Average ticket price$121
Average bus trip duration17h 45m
Number of daily buses3
Earliest bus departure1:40am
Distance509 miles (820 km)
Latest bus departure4:15pm

St Louis to Greenville Bus

With Busbud, comparing and booking tickets for a bus from St Louis to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from St Louis to Greenville.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from St Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip St Louis - Greenville

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
04/23
$162
04/24
No data
Today
No data
04/26
No data
04/27
$113
04/28
No data
04/29
No data
04/30
No data
busbud logoThe cheapest trip from St Louis to Greenville was searched and found on Apr 27, 2025 with a price of $113

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St Louis to Greenville, as early as possible.

You can expect to pay from $113 to $162 for a bus ticket from St Louis to Greenville based on the last 2 days. You can expect to find the cheapest price for the trip at $113 which is on 2025-04-27.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from St Louis to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from St Louis to Greenville.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St Louis to Greenville.

Tune out to the fine sounds of your best music playlist on your bus trip from St Louis to Greenville while indulging in miles on end of beautiful scenic views.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from St Louis to Greenville?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St Louis by bus?

Bus from St Louis to Greenville

You can also go to Greenville by train

Train from St Louis to Greenville

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