Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Holiday Inn Guatemala City | Gasolinera Puma | No tags | |||||
| Holiday Inn Guatemala City | Gasolinera Puma | No tags | |||||
 | Hotel las Americas | Fertica Santa Ana | No tags | |||||
| Metroplaza Guatemala | Fertica Santa Ana | No tags | |||||
| Hotel las Americas | Fertica Santa Ana | No tags |
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Get from Guatemala City to Santa Ana
The journey takes about 4 hours and with fares starting at just $35, it presents an excellent value for a comfortable ride.
Bus Guatemala City to Santa Ana, SV: Trip Overview
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Guatemala City to Santa Ana Bus
Busbud helps you find a bus from Guatemala City to Santa Ana. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make sure you can find a bus service from Guatemala City to Santa Ana from the most reliable bus companies operating this trip.
Whether it is cheap bus tickets or more luxurious buses going to Santa Ana from Guatemala City, we help you find what you're looking for based on how much of a budget you have.
Frequently asked questions for your trip Guatemala City - Santa Ana, SV
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Guatemala City to Santa Ana, SV was searched and found on Oct 29, 2025 with a price of $88To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Guatemala City to Santa Ana, SV, as early as possible.
You can expect to pay from $88 to $88 for a bus ticket from Guatemala City to Santa Ana, SV based on the last 2 days. You can expect to find the cheapest price for the trip at $88 which is on 2025-11-01.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Guatemala City and Santa Ana!
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Guatemala City to Santa Ana, get comfy and count the stars.
Buses are energy-efficient. Carrying a passenger over 100 kms by bus only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Guatemala City to Santa Ana.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Guatemala City to Santa Ana.
Did you know?
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
Top traveled bus routes
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Popular Buses Connecting Guatemala City
Buses Leaving from Guatemala City
- Bus from Guatemala City to León
- Bus Guatemala City - Ahuachapan
- Guatemala City - San Miguel
- Bus from Guatemala City to San José
- Bus Guatemala City - Sébaco
- Guatemala City - Orotina
- Bus from Guatemala City to Ocotal
- Bus Guatemala City - Tipitapa
- Guatemala City - Choluteca
- Bus from Guatemala City to Nandaime
- Bus Guatemala City - Rivas
- Guatemala City - La Union
- Bus from Guatemala City to Esteli
- Bus Guatemala City - EL AMATILLO
- Guatemala City - Liberia
Buses Going to Guatemala City
- Bus from La Libertad to Guatemala City
- Bus Ahuachapan - Guatemala City
- San Miguel - Guatemala City
- Bus from Tipitapa to Guatemala City
- Bus Esteli - Guatemala City
- Choluteca - Guatemala City
- Bus from Sébaco to Guatemala City
- Bus La Union - Guatemala City
- Ocotal - Guatemala City
- Bus from San Isidro to Guatemala City
- Bus EL AMATILLO - Guatemala City