Bus Tickets from San Diego, CA to St Louis, MO

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Bus San Diego to St Louis: Trip Overview

Average ticket price$189
Average bus trip duration1d 22h
Number of daily buses13
Earliest bus departure7:15am
Distance1559 miles (2514 km)
Latest bus departure7:35pm

San Diego to St Louis Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from San Diego to St Louis.

We make sure you can find a bus service from San Diego to St Louis from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from San Diego to St Louis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip San Diego - St Louis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
04/22
$184
04/23
$250
Today
$129
04/25
No data
04/26
$139
04/27
No data
04/28
No data
04/29
No data
busbud logoThe cheapest trip from San Diego to St Louis was searched and found on Apr 24, 2025 with a price of $129

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego to St Louis, as early as possible.

You can expect to pay from $129 to $288 for a bus ticket from San Diego to St Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $139 which is on 2025-04-26.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from San Diego to St Louis but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Diego to St Louis, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to St Louis that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from San Diego to St Louis while indulging in miles on end of beautiful scenic views.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

What's the cheapest way to go from San Diego to St Louis?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to San Diego by bus?

Bus from San Diego to St Louis

You can also go to St Louis by train

Train from San Diego to St Louis

Why choose Busbud?

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Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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