Bus Tickets from St Louis, MO to San Diego, CA

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Compare 2 ways to go from St Louis to San Diego.

Bus
Average Price$94 - $366Average Duration2d
63kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$219 - $389Average Duration2d 8h
229kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from St Louis to San Diego

Among the sustainable travel choices, the bus stands out as the good way to reach San Diego. The journey takes about 2 days, 5 minutes and with fares starting at just $94, it presents an excellent value for a comfortable ride.

16bus per day
2d Average Duration
$94Cheapest ticket
63kgCO₂ emissions

Bus St Louis to San Diego: Trip Overview

Average ticket price$210
Average bus trip duration2d
Number of daily buses16
Earliest bus departure1:35am
Distance1557 miles (2510 km)
Latest bus departure7:00pm

St Louis to San Diego Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from St Louis to San Diego.

We make sure you can find a bus service from St Louis to San Diego from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to San Diego from St Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip St Louis - San Diego

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
04/27
$291
04/28
$277
Today
$255
04/30
No data
05/01
$197
05/02
No data
05/03
No data
05/04
No data
busbud logoThe cheapest trip from St Louis to San Diego was searched and found on May 1, 2025 with a price of $197

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St Louis to San Diego, as early as possible.

You can expect to pay from $197 to $428 for a bus ticket from St Louis to San Diego based on the last 2 days. You can expect to find the cheapest price for the trip at $197 which is on 2025-05-01.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from St Louis to San Diego but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from St Louis to San Diego, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St Louis to San Diego.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St Louis to San Diego.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

What's the cheapest way to go from St Louis to San Diego?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St Louis by bus?

Bus from St Louis to San Diego

You can also go to San Diego by train

Train from St Louis to San Diego

Why choose Busbud?

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Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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